Chinese social norms dating

25 Jul

I said yesterday I would say a bit more about the new paper on rapid recent high altitude adaptation among the Tibetans when I’d read the paper. Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude: Residents of the Tibetan Plateau show heritable adaptations to extreme altitude.

We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual.

As to that last point…the timing of this has been causing a major problem with archaeologists.

HIF-1 and EPAS1 each act on a unique set of regulatory targets…and the narrower expression profile of EPAS1 includes adult and fetal lung, placenta, and vascular endothelial cells…A protein-stabilizing mutation in EPAS1 is associated with erythrocytosis…suggesting a link between EPAS1 and the regulation of red blood cell production.

Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.

The exome is just the protein-coding part of the genome; so they’re focusing ostensibly on functionally relevant single nucleotide polymorphisms (SNPs).

Figure 1 is rather striking, so let’s jump to it: This chart is simply showing frequencies of SNPs in Tibetans and Han.

The two are obviously correlated, as evident by the diagonal.