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21 Feb

Smallpox epidemics are thought to have caused the greatest loss of life for indigenous populations.

William M Denevan, noted author and Professor Emeritus of Geography at the University of Wisconsin-Madison, said on this subject in his essay "The Pristine Myth: The Landscape of the Americas in 1492"; "The decline of native American populations was rapid and severe, probably the greatest demographic disaster ever. In many regions, particularly the tropical lowlands, populations fell by 90 percent or more in the first century after the contact.

The ancestors of modern Native Americans arrived in what is now the United States at least 15,000 years ago, possibly much longer, from Asia through Beringia.

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Even before the European settlement of what is now the United States, Native Americans suffered high fatalities from contact with new European diseases, to which they had not yet acquired immunity; the diseases were endemic to the Spanish and other Europeans, and spread by direct contact and likely through pigs that escaped from expeditions.

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Since the end of the 15th century, the migration of Europeans to the Americas has led to centuries of population, cultural, and agricultural transfer and adjustment between Old and New World societies, a process known as the Columbian exchange.

As most Native American groups had historically preserved their histories by oral traditions and artwork, the first written sources of the conflict were written by Europeans.